Description
Tesamorelin is a synthetic peptide drug (a form of growth hormone–releasing hormone, GHRH analog) used to stimulate the body to produce growth hormone (GH)—and, as a result, IGF‑1 (insulin-like growth factor 1).
High-level what it’s used for
It’s commonly prescribed for:
– Reducing excess abdominal fat in people with HIV-associated lipodystrophy (a redistribution of body fat).
(This is the main well-known approved indication in many jurisdictions.)
How it works (conceptually)
– Tesamorelin acts on the pituitary gland
– It increases GH secretion
– GH increases IGF‑1 production, which affects growth and metabolism
Important context
– It’s a prescription medication in countries where approved, not a general supplement.
– Like other hormones that affect the GH/IGF‑1 axis, it can have side effects and requires medical supervision.

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